TetraHer is our new tool for estimating liability heritability of binary phenotypes (i.e., diseases). QuantHer is an analogous method for estimating heritability of quantitative phenotypes. Note that TetraHer and QuantHer are for use when you have individual-level data for related samples; if you have individual-level data for unrelated samples, then you likely wish to estimate SNP heritability using REML, Haseman-Elston Regression or PCGC.
Always read the screen output, which suggests arguments and estimates memory usage.
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TetraHer:
The main argument is --family-binary <outfile>.
This requires the options
--relatives <pairsfile> - to specify pairs of related individuals.
--pheno <phenofile> - to specify phenotypes (in PLINK format). Samples without a phenotype will be excluded. If <phenofile> contains more than one phenotype, specify which should be used with --mpheno <integer>.
To be completed
